Postdoctoral Research Associate - Structural Biology - BEORHN Project
Diamond Light Source is the UK’s national 3rd generation synchrotron science facility. By accelerating electrons to near light-speed, Diamond generates brilliant beams of light from infra-red to X-rays which are used for academic and industry research and development across a range of scientific disciplines including structural biology, physics, chemistry, materials science, engineering, earth and environmental sciences.
Diamond is one of the most advanced scientific facilities in the world, and its pioneering capabilities and talented staff are helping to keep the UK at the forefront of scientific research.
About the Role
As part of a BBSRC funded collaborative project between Diamond Light Source, STFC Daresbury Laboratory, University of Essex and University of Bristol, we are looking to recruit a highly motivated and experienced researcher at the Post-Doctoral Research Associate level to characterise heme P460-containing enzymes that catalyse critical reactions of the nitrification pathway of the nitrogen cycle. Such reactions are globally important for making nitrogen bioavailable.
The successful candidate will determine X-Ray crystal structures of these enzymes and their site-directed mutants in different, validated redox and ligand states, and carry out time resolved crystallography experiments to characterise reactivity. You will work closely with other PDRA researchers carrying out computational studies of these enzymes as part of a broad collaborative team. The project will involve a wide-ranging of state-of-the-art structural biology methods including serial crystallography and single crystal spectroscopy. You will have the opportunity to participate in state-of-the-art experiments both at Diamond and other leading international synchrotron or X-Ray free electron laser facilities.
You will have experience in the recombinant production and purification of proteins and knowledge of protein crystallisation, data collection and processing. Within this project, you will gain experience of how experimental structural biology may be linked to advanced computational simulations in order to fully understand enzyme reactivities. You will benefit from an outstanding interdisciplinary training environment.
Diamond offers an exceptional benefits package to support staff in achieving a positive work/life balance. This includes 25 days annual leave plus 13 days of statutory and company holidays, along with flexible working hours and an excellent pension scheme. Staff also have access to a range of amenities on site including a nursery, cafes, a restaurant and sports and leisure facilities. A relocation allowance may also be available where applicable.
We take an active approach to ensuring equality, diversity and inclusion are at the heart of our activities at Diamond, with a dedicated commitment to ensuring we provide a fulfilling and enjoyable place to work, where all staff feel valued and recognised for their individual contribution.
Applicants are required to outline their suitability for this role via the online application process. Please also state where you saw this role advertised.
The closing date for applications is 24/10/2021 and interviews will be scheduled shortly afterwards.
Where relevant, and possible for the role, we will consider flexible working arrangements and secondment opportunities.
Diamond attract talented individuals from around the world and currently employ 44 different nationalities. Reflecting trends in our sector we employ more men than women (77% men and 23% women as at March 2021). Therefore, in accordance with law and good practice, we particularly welcome applications from suitably qualified women.
If you are disabled and would like to be considered under the Guaranteed Interview Scheme, please let us know via the online application process.
Diamond are members of Working Families (the UK’s work-life balance organisation), we have also achieved the Athena SWAN Bronze award and Disability Confident Level One.