Principal Beamline Scientist - I03

About Us

Diamond Light Source is the UK’s national 3rd generation synchrotron science facility. Life sciences is a significant strength at Diamond with structural biology being a major driver. Diamond currently has 7 world-class beamlines dedicated to macromolecular crystallography (MX) covering a diverse and unique set of capabilities. MX is complemented by dedicated beamlines for BIOSAXS, CD, X-ray imaging and spectroscopy, IR-micro-spectroscopy and the UK’s national Cryo-EM centre (eBIC), together creating a unique environment for integrative structural biology research.

The MX group at Diamond established the first dedicated synchrotron-based labs for X-ray fragment screening (XChem) and membrane proteins (MPL). In addition, the UK XFEL Hub provides a focus for XFEL work, engaging UK users in serial crystallography experiments around the world and directs UK developments at the SPB/SFX instrument at the European XFEL. The MX group has a strong software development programme which includes development of the DIALS integration software package, ISPyB/SynchWeb and automation pipelines.

About the Role

We now have an opportunity for a Principal Beamline Scientist (PBS) with a keen interest in beamline development, automation and/or structural biology, to join the macromolecular crystallography (MX) leadership team within Diamond to guide and develop the highly automated I03 beamline.

I03 is a state-of-the-art macromolecular crystallography beamline at Diamond, uniquely being capable of collecting data from crystalline samples up to biological containment level 3. It has a broad energy range and is equipped with a state-of-the-art detector (Eiger2 XE 16M) and very high capacity, rapid sample changer (BART). To date the team has led many of the developments for cryogenic sample automation and automated data collection.

In the role of PBS you will manage a small team of scientists to establish a programme which furthers the capabilities of I03 and MX at Diamond and contribute to the development and operation of the I03/MX group international user programme.

The post is underpinned by funding for a post-doctoral research associate to support research and development within the group subject to a suitable case being made. Furthermore, Diamond has a successful PhD programme and is partnered with a number of doctoral training centres across the UK providing the opportunity for PhD studentships. You will have access to well-equipped laboratories for structural and cellular biology at Diamond and within the Research Complex at Harwell.

Instrumentation and software development is facilitated by dedicated support from Diamond’s computing, engineering and scientific software groups as well as strategic partnerships with CCP4 and the recently established Rosalind Franklin Institute amongst others. Candidates are encouraged to apply for external grant funding through national and international funding agencies to take full advantage of the stimulating and exciting research environment at Diamond.

Looking to the future, the expected Diamond-II upgrade programme of machine and beamlines presents a unique opportunity for the post holder to develop advanced methodologies in automation for MX and a complementary user programme for I03 for structural biology studies, including where appropriate exploiting the beamlines unique biological containment level 3 capability.

About You

You will hold appropriate first and higher degrees or demonstrate significant equivalent experience.

You will be a highly talented structural biologist or methods development expert, with expertise in macromolecular crystallographic techniques as applied at synchrotron beamlines, and a broad outlook in structural biology.

Experience of beamline instrumentation, experiment automation and/or sample environment equipment, biological containment environments, will benefit your application.

You will demonstrate skills in managing a small team, as well as a managing a budget and other resources for research and operations and upgrade projects.

You will have demonstrated ability to develop a research programme, and to lead significant projects.

You will display excellent interpersonal, communication and presentational skills, to interact effectively with staff and stakeholders at all levels.


Diamond offers an exceptional benefits package to support staff in achieving a positive work/life balance. This includes 25 days annual leave plus 13 days of statutory and company holidays, along with flexible working hours and an excellent pension scheme. Staff also have access to a range of amenities on site including a nursery, cafes, a subsidised restaurant and sports and leisure facilities. A relocation allowance may also be available where applicable.

To Apply

Please use the online application process to apply and tell us why you believe you are suitable for this role.

Business Area
Full Time Salary
£55,097 to £64,821 per annum (Discretionary range to £74,545)
Post Type
Full time / Permanent
Closing Date
Ref No


Other information


Where relevant, and possible for the role, we will consider flexible working arrangements and secondment opportunities.

Diamond attract talented individuals from around the world and currently employ 44 different nationalities.  Reflecting trends in our sector we employ more men than women (77% men and 23% women as at March 2021). Therefore, in accordance with law and good practice, we particularly welcome applications from suitably qualified women. 

If you are disabled and would like to be considered under the Guaranteed Interview Scheme, please let us know via the online application process.

Diamond are members of Working Families (the UK’s work-life balance organisation), we have also achieved the Athena SWAN Bronze award and Disability Confident Level One.